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Types of Cancer > OncoLink Vet > Veterinary Oncology > Tumors
Subungual Squamous Cell Carcinoma
Supported by the Savannah and Barry French Poodle Memorial Fund
Affiliation:
University of Pennsylvania School of Veterinary Medicine
Last Modified: August 21, 2005
Michael H. Goldschmidt, MSc, BVMS, MRCVS, Diplomate ACVP Professor and Head, Laboratory of Pathology and Toxicology Chief, Surgical Pathology Department of Pathobiology
Frances S. Shofer, PhD, Adjunct Associate Professor of Epidemiology and Biostatistics
Introduction
Definition: A malignant tumor of epidermal cells with varying degrees of keratinocyte (squamous cell) differentiation
Synonyms: digital squamous cell carcinoma
Subungual SCC involves the nailbed of the canine paw. These tumors are most often solitary neoplasms, although multiple tumors on different digits have been found on some dogs.
Etiology/Epidemiology
Whereas cutaneous squamous cell carcinoma is associated with ultraviolet light exposure, there is no such association with subungual squamous cell carcinomas. However, the relationship between previous papilloma virus infection and subsequent development of subungual squamous cell carcinomas awaits further investigation.
| Sex | N | Percent |
| Female | 251 | 17% (21%) |
| Female Spayed | 523 | 36% (33%) |
| Male | 378 | 26% (25%) |
| Male Castrated | 306 | 21% (21%) |
| (Normal Population %) |
| Breeds at Increased Risk |
N | Probability | OR | 95% Confidence Interval |
|
| Giant Schnauzer | 37 | <0.0001 | 22.7 | 16.0 | 32.3 |
| Gordon Setter | 28 | <0.0001 | 11.1 | 7.5 | 16.3 |
| Briard | 10 | <0.0001 | 10.4 | 5.5 | 19.8 |
| Kerry Blue Terrier | 19 | <0.0001 | 7.7 | 4.8 | 12.2 |
| Standard Poodle | 96 | <0.0001 | 5.9 | 4.8 | 7.2 |
| Rottweiler | 166 | <0.0001 | 5.7 | 4.8 | 6.7 |
| Flat Coated Retriever | 5 | 0.00530 | 4.6 | 1.9 | 11.3 |
| Scottish Terrier | 42 | <0.0001 | 4.2 | 3.1 | 5.7 |
| Standard Schnauzer | 41 | <0.0001 | 3.8 | 2.8 | 5.2 |
| Afghan Hound | 9 | 0.00190 | 3.4 | 1.7 | 6.5 |
| Dachshund | 40 | <0.0001 | 2.2 | 1.6 | 3.0 |
| Labrador Retriever | 214 | <0.0001 | 2.0 | 1.7 | 2.3 |
| Breeds at Decreased Risk |
N | Probability | OR | 95% Confidence Interval |
|
| German Shepherd | 41 | 0.01170 | 0.67 | 0.49 | 0.92 |
| Husky | 9 | 0.00550 | 0.42 | 0.22 | 0.81 |
| Golden Retriever | 43 | <0.0001 | 0.40 | 0.30 | 0.54 |
| Lhasa Apso | 5 | 0.00750 | 0.37 | 0.17 | 0.83 |
| Yorkshire Terrier | 6 | 0.00250 | 0.33 | 0.15 | 0.74 |
| English Springer Spaniel | 9 | 0.00019 | 0.30 | 0.14 | 0.63 |
| Basset Hound | 4 | 0.00210 | 0.27 | 0.10 | 0.73 |
| Boston Terrier | 2 | 0.02940 | 0.25 | 0.06 | 1.01 |
| Boxer | 10 | <0.0001 | 0.23 | 0.13 | 0.43 |
| Shetland Sheepdog | 5 | <0.0001 | 0.18 | 0.07 | 0.42 |
| Collie | 2 | 0.00076 | 0.16 | 0.04 | 0.65 |
| Maltese | 1 | 0.01780 | 0.15 | 0.02 | 1.07 |
| Samoyed | 1 | 0.01830 | 0.15 | 0.02 | 1.03 |
| Beagle | 3 | <0.0001 | 0.10 | 0.03 | 0.30 |
