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Types of Cancer > OncoLink Vet > Veterinary Oncology > Tumors
Tumors with Differentiation to Hair Follicular Structures
Supported by the Savannah and Barry French Poodle Memorial Fund
Affiliation:
University of Pennsylvania School of Veterinary Medicine
Last Modified: August 21, 2005
Michael H. Goldschmidt, MSc, BVMS, MRCVS, Diplomate ACVP Professor and Head, Laboratory of Pathology and Toxicology Chief, Surgical Pathology Department of Pathobiology
Frances S. Shofer, PhD, Adjunct Associate Professor of Epidemiology and Biostatistics
Introduction
These tumors show differentiation to hair follicular structures. There is a marked variability in the histopathologic appearance of these tumors, and there may be some variability within a single tumor when examined by light microscopy. This variability is due to the complex histology of the normal hair which is mimicked by these tumors showing hair follicular differentiation.
During embryologic development of the skin and adnexal structures the pilar germ emerges at an angle from the underside of the epidermis. Under the influence of inductive mesenchymal cells, which will form the papillum of the hair, the cells extend into the deep dermis. Here differentiation of the hair germ in to the hair bulb occurs. The hair shaft, the outer root sheath and inner root sheath are formed from the hair bulb.
- Infundibular Keratinizing Acanthoma
- Tricholemmoma
- Inferior Tricholemmoma
- Isthmic Tricholemmoma
- Trichoblastoma
- Trichoepithelioma
- Malignant Trichoepithelioma
- Pilomatricoma
- Malignant Pilomatricoma
- References
Infundibular Keratinizing Acanthoma (IKA)
Introduction
Definition: A benign tumor characterized by peripheral proliferation of basaloid epithelial cells with differentiation to squamous epithelium resembling the normal follicular infundibulum/isthmus.
Synonyms: Intracutaneous Cornifying Epithelioma (ICE), Squamous Papilloma